Melanoma
The following list provides a brief description of melanoma trials that are open for recruitment in Western Australia. If you would like more information please follow the links provided, contact one of the trial sites or speak with your doctor.
Please note that this list is based on information provided to the Cancer Council by WA hospitals and may not include all clinical trials that are running in WA.
Where ‘N/A' appears - this means the lacking information has not been provided to date to the Cancer Council.
EAP Melanoma Study
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Registered Title |
An Open-label, Multicenter Expanded Access Study of RO5185426 in Patients With Metastatic Melanoma. |
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Purpose |
This open-label, multicenter, expanded access study will evaluate the safety and efficacy of RO5185426 in patients with BRAF V600 mutation-positive metastatic melanoma who have failed at least one previous systemic treatment for metastatic melanoma and are without satisfactory treatment options. Eligible patients will receive RO5185426 (960 mg twice daily orally) until disease progression or unacceptable toxicity occurs. |
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Lay Summary |
N/A |
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WA Trial Sites |
SCGH Medical Oncology |
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Links |
Acknowledgements: US National Library of Medicine
EISAI E7080 Melanoma
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Registered Title |
An Open-Label, 2-Cohort, Multicenter, Phase 2 Study of E7080 in Previously Treated Subjects With Unresectable Stage III or Stage IV Melanoma. |
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Purpose |
The purpose of this study is to assess the objective response rate of E7080 in previously treated subjects with American Joint Committee on Cancer (AJCC) unresectable stage III or stage IV melanoma and disease progression. |
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Lay Summary |
N/A |
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WA Trial Sites |
SCGH Medical Oncology |
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Links |
Acknowledgements: US National Library of Medicine
Tin Foil Nose Study
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Registered Title |
Tin Foil Nose Study - Prospective follow up study of all Skin cancers of the nose treated with the PRO Tin Foil technique. |
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Purpose |
To assess the cosmetic outcomes of the Tin foil technique for treating non-melanomatous skin cancers of the nose. The second aim is to assess the impact of this treatment on patients' quality of life and assess their satisfaction with the treatment. |
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Lay Summary |
There are a number of different treatments available for the treatment of non-melanomatous skin cancer. These include radiation treatment, moh's surgery, electrodessication, curettage (EDC) and local excision. There is very little information on patient's quality of life following radiation. In Australia the cost of radiation treatment is not as high as in United States which means that it is an alternate treatment to surgery.
The technical aspects of the tin foil technique developed at PRO have been presented in the past, but there is little on the patient's satisfaction with the outcome. This study looks at local recurrence rates, patterns of recurrence, acute and late side effects of radiation, cosmesis (what the nose looks like from both doctors and patients viewpoint) and patients' quality of life pre and post treatment and satisfaction with the treatment overall. |
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WA Trial Sites |
Perth Radiation Oncology Centre |
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Links |
N/A |
Whole Brain Radiotherapy (WBRT) Melanoma
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Registered Title |
Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma- A randomized phase III trial. |
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Purpose |
To find out whether whole brain radiotherapy after treatment (surgery /radiation focused on the tumour site) is able to defer the spread of melanoma cancer in the brain and to determine the effect of adding WBRT to local treatment on distant intracranial control (primary), quality of life (QoL), performance status, neurocognitive function (NCF) and overall survival.
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Lay Summary |
To investigate the effect of adding whole brain radiotherapy after surgery and or stereotactic irradiation on the development of further brain metastases in participants with melanoma. |
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WA Trial Sites |
SCGH Radiation Oncology |
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Links |
Acknowledgements: US National Library of Medicine
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