Gynaecological
he following list provides a brief description of gynaecological cancer trials that are open for recruitment in Western Australia. If you would like more information please follow the links provided, contact one of the trial sites or speak with your doctor.
Please note that this list is based on information provided to the Cancer Council by WA hospitals and may not include all clinical trials that are running in WA.
Where ‘N/A' appears - this means the lacking information has not been provided to date to the Cancer Council.
EMPOWER
Registered Title | An Open-Label, Randomized, Phase 3 Clinical Trial of REGN2810 Versus Therapy of Investigator's Choice Chemotherapy in Recurrent or Metastatic Platinum-Refractory Cervical Carcinoma |
Purpose | The primary objective is to compare overall survival (OS) for patients with recurrent or metastatic platinum-refractory cervical cancer treated with either REGN2810 or investigator's choice (IC) chemotherapy. |
Lay Summary | N/A |
WA Trial Sites |
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Links |
US National Library of Medicine |
Acknowledgements: US National Library of Medicine
feMMe Endometrial Cancer Study
Registered Title |
A Phase II Randomised Clinical Trial of Mirena® ± Metformin ± Weight Loss Intervention in Patients With Early Stage Cancer of the Endometrium. |
Purpose |
Currently the standard treatment for early stage endometrial cancer or endometrial hyperplasia with atypia is a total hysterectomy (an operation to remove the uterus) and removal of both ovaries. While highly effective, this surgery carries significant side effects for:
This study will access a new approach to the treatment of endometrial cancer to spare women of having to undergo major surgery that may be unwanted or unnecessary. Mirena is approved in Australia for contraception, to treat heavy bleeding, and to prevent thickening of the lining of the uterus (endometrial hyperplasia) during oestrogen replacement therapy (HRT). However it is not approved to treat early stage endometrial cancer or endometrial hyperplasia with atypia. This research project will test to see if Mirena is an effective treatment for early stage endometrial cancer and endometrial hyperplasia with atypia. Metformin is approved in Australia to treat Diabetes. However it is not approved to treat early stage endometrial cancer or endometrial hyperplasia with atypia. Therefore, it is an experimental treatment for early stage endometrial cancer and endometrial hyperplasia with atypia. This means that it must be tested to see if it is an effective treatment for early stage endometrial cancer and endometrial hyperplasia with atypia. Weight loss interventions are feasible and safe, and already being implemented by gynaecologic oncologist to make women eligible for surgery. Weight loss of 7% body weight induces a large biological effect (for example reduces incidence of diabetes by 58%, and hypertension by 26%). |
Lay Summary |
N/A |
WA Trial Sites |
St John of God |
Links |
Acknowledgements: US National Library of Medicine
FROCS
Registered Title |
Mindfulness Based Cognitive Therapy for Fear of Recurrence in Ovarian Cancer Survivors. (FROCS) |
Purpose |
This study will determine the effect of mindfulness based cognitive therapy on the fear of recurrence in ovarian cancer survivors. |
Lay Summary
|
Who is it for? You may be eligible to join this study if you are aged 18 years or above and have been diagnosed with ovarian cancer, have completed all hospital based adjuvant treatment and are now disease free. Study details: All participants will receive the same intervention and will involve intensive training and practice in mindfulness based cognitive therapy. Treatment is designed as an 8 week course of 2-2.5 hour small group sessions once weekly with approximately 8-15 individuals in each group. Sessions are run at locations in Shenton Park, Duncraig and East Fremantle by the Cancer Council WA, or by SolarisCare Foundation, at Sir Charles Gardner Hospital in Nedlands. Courses take place during the day and are free of charge. The groups will be run by experienced clinicians in psychotherapy, counselling and meditation and will have a clinician manual and a participant workbook outlining the themes and exercises for each week. Group members will be expected to practice skills between sessions. Participants will be asked to answer questionnaires before, during and after the group sessions to collect information on how participants are feeling. |
WA Trial Sites |
St John of God |
Links |
Acknowledgements: Australian and New Zealand Clinical Trials Registry
LACC Cervical Cancer Study
Registered Title |
A Phase III Randomized Clinical Trial of Laparoscopic or Robotic Radical Hysterectomy Versus Abdominal Radical Hysterectomy in Patients With Early Stage Cervical Cancer. |
Purpose |
The goal of this clinical research study is to compare the long-term outcomes of different surgical methods for the treatment of cervical cancer. The long-term outcome of a total abdominal radical hysterectomy (TARH) will be compared against laparoscopy. In this study, the laparoscopy will be done with or without robotic technology. |
Lay Summary |
N/A |
WA Trial Sites |
St John of God |
Links |
Acknowledgements: US National Library of Medicine
PHAEDRA
Registered Title |
"A Phase II trial of durvalumab (Medi 4736) in advanced endometrial cancer A multi-centre Phase II trial to determine the activity and safety of durvalumab in advanced endometrial cancer" |
Purpose
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The primary purpose of this trial is to evaluate the safety and efficacy of durvalumab for the treatment of advanced endometrial cancer. Who is it for? You may be eligible to enroll in this trial if you are aged 18 or over and have been diagnosed with advanced endometrial carcinoma which is suitable for chemotherapy. |
Lay Summary | N/A |
WA Trial Sites | ![]() |
Links |
Australian New Zealand Clinical Trials Registry |
Acknowledgements: Australian and New Zealand Clinical Trials Registry
Statec
Registered Title | A randomised trial of nonselective versus selective adjuvant therapy in high risk apparent stage 1 endometrial cancer. |
Purpose | Who is it for? |
Lay Summary | This study is testing the use of a surgical procedure called lymphadenectomy (or lymph gland removal) to help guide further treatment in women with endometrial (womb) cancer. |
WA Trial sites | |
Links |
EXCISE
Registered Title |
Excisional treatment in women with cervical adenocarcinoma-in-situ (AIS): a prospective randomised controlled non-inferiority trial to compare AIS persistence/recurrence after loop electrosurgical excision procedure to cold knife cone biopsy. |
Purpose | The aim of this pilot study is to compare loop electrosurgical excision procedure to cold knife cone biopsy for treatment of adenocarcinoma in situ. |
Lay Summary |
Who is it for? Study details |
WA Trial Sites |
St John of God - Subiaco (08) 6465 9204 |
Links | Australian and New Zealand Clinical Trials Registry |
Acknowledgements: Australian and New Zealand Clinical Trials Registry
iPRIME
Registered Title |
A Phase II Study of Durvalumab and Tremelimumab in combination with Neoadjuvant Carboplatin and Paclitaxel in newly diagnosed women with advanced high grade Serous Ovarian, Fallopian Tube and Peritoneal Cancers “iPRIMEâ€. |
Purpose | The purpose of this research project is to test how safe and effective the combination treatment of durvalumab and tremelimumab in combination with standard chemotherapy is as a treatment for patients with ovarian, fallopian tube or peritoneal cancers. |
Lay Summary |
Who is it for? Study details |
WA Trial Sites |
Linear Clinical Research 0437 873 044 |
Links | Australian and New Zealand Clinical Trials Registry |
Acknowledgements: Australian and New Zealand Clinical Trials Registry
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